Self-Assembling Lecithin-Based Mixed Polymeric Micelles for Nose to Brain Delivery of Clozapine: In-vivo Assessment of Drug Efficacy via Radiobiological Evaluation

PURPOSE: The research objective is to design intranasal brain targeted CLZ loaded lecithin based polymeric micelles (CLZ- LbPM) aiming to improve central systemic CLZ bioavailability. METHODS: In our study, intranasal CLZ loaded lecithin based polymeric micelles (CLZ- LbPM) were formulated using soy...

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Detalles Bibliográficos
Autores principales: M Elsharkawy, Fatma, M Amin, Maha, A Shamsel-Din, Hesham, Ibrahim, Walaa, Ibrahim, Ahmed B, Sayed, Sinar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065422/
https://www.ncbi.nlm.nih.gov/pubmed/37007986
http://dx.doi.org/10.2147/IJN.S403707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065422/
https://www.ncbi.nlm.nih.gov/pubmed/37007986
http://dx.doi.org/10.2147/IJN.S403707

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