Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions

Biomolecular condensates participate in the regulation of gene transcription, yet the relationship between nuclear condensation and transcriptional activation remains elusive. Here, we devised a biotinylated CRISPR-dCas9–based optogenetic method, light-activated macromolecular phase separation (LAMP...

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Detalles Bibliográficos
Autores principales: Kim, Yoon Jung, Lee, Michael, Lee, Yi-Tsang, Jing, Ji, Sanders, Jacob T., Botten, Giovanni A., He, Lian, Lyu, Junhua, Zhang, Yuannyu, Mettlen, Marcel, Ly, Peter, Zhou, Yubin, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065442/
https://www.ncbi.nlm.nih.gov/pubmed/37000871
http://dx.doi.org/10.1126/sciadv.adg1123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065442/
https://www.ncbi.nlm.nih.gov/pubmed/37000871
http://dx.doi.org/10.1126/sciadv.adg1123

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