Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly

The elimination of aberrant inclusions is regarded as a therapeutic approach in neurodegeneration. In amyotrophic lateral sclerosis (ALS), mutations in proteins found within cytoplasmic condensates called stress granules (SGs) are linked to the formation of pathological SGs, aberrant protein inclusi...

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Detalles Bibliográficos
Autores principales: Kassouf, Toufic, Shrivastava, Rohit, Meszka, Igor, Bailly, Aymeric, Polanowska, Jolanta, Trauchessec, Helene, Mandrioli, Jessica, Carra, Serena, Xirodimas, Dimitris P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065448/
https://www.ncbi.nlm.nih.gov/pubmed/37000881
http://dx.doi.org/10.1126/sciadv.abq7585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065448/
https://www.ncbi.nlm.nih.gov/pubmed/37000881
http://dx.doi.org/10.1126/sciadv.abq7585

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