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Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly
The elimination of aberrant inclusions is regarded as a therapeutic approach in neurodegeneration. In amyotrophic lateral sclerosis (ALS), mutations in proteins found within cytoplasmic condensates called stress granules (SGs) are linked to the formation of pathological SGs, aberrant protein inclusi...
Autores principales: | Kassouf, Toufic, Shrivastava, Rohit, Meszka, Igor, Bailly, Aymeric, Polanowska, Jolanta, Trauchessec, Helene, Mandrioli, Jessica, Carra, Serena, Xirodimas, Dimitris P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065448/ https://www.ncbi.nlm.nih.gov/pubmed/37000881 http://dx.doi.org/10.1126/sciadv.abq7585 |
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