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PI(4,5)P(2)-dependent regulation of endothelial tip cell specification contributes to angiogenesis
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P(2) to PI(3,4,5)P(3), activating AKT; however, PI3K/AKT does not direct tip cell specification. We report t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065449/ https://www.ncbi.nlm.nih.gov/pubmed/37000875 http://dx.doi.org/10.1126/sciadv.add6911 |