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PI(4,5)P(2)-dependent regulation of endothelial tip cell specification contributes to angiogenesis

Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P(2) to PI(3,4,5)P(3), activating AKT; however, PI3K/AKT does not direct tip cell specification. We report t...

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Detalles Bibliográficos
Autores principales:	Davies, Elizabeth M., Gurung, Rajendra, Le, Kai Qin, Roan, Katherine T. T., Harvey, Richard P., Mitchell, Geraldine M., Schwarz, Quenten, Mitchell, Christina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065449/ https://www.ncbi.nlm.nih.gov/pubmed/37000875 http://dx.doi.org/10.1126/sciadv.add6911

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