Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

Darunavir (DRV) is exceptional among potent HIV-1 protease inhibitors (PIs) in high drug concentrations that are achieved in vivo. Little is known about the de novo resistance pathway for DRV. We selected for resistance to high drug concentrations against 10 PIs and their structural precursor DRV. M...

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Detalles Bibliográficos
Autores principales: Spielvogel, Ean, Lee, Sook-Kyung, Zhou, Shuntai, Lockbaum, Gordon J, Henes, Mina, Sondgeroth, Amy, Kosovrasti, Klajdi, Nalivaika, Ellen A, Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A, Swanstrom, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065791/
https://www.ncbi.nlm.nih.gov/pubmed/36920025
http://dx.doi.org/10.7554/eLife.80328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065791/
https://www.ncbi.nlm.nih.gov/pubmed/36920025
http://dx.doi.org/10.7554/eLife.80328

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