PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA repair templates in human cord blood-derived, naive...

Descripción completa

Detalles Bibliográficos
Autores principales: Anderson, Warren, Barahmand-pour-Whitman, Fariba, Linsley, Peter S, Cerosaletti, Karen, Buckner, Jane H, Rawlings, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065793/
https://www.ncbi.nlm.nih.gov/pubmed/36961507
http://dx.doi.org/10.7554/eLife.81577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065793/
https://www.ncbi.nlm.nih.gov/pubmed/36961507
http://dx.doi.org/10.7554/eLife.81577

Ejemplares similares