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PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA repair templates in human cord blood-derived, naive...

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Detalles Bibliográficos
Autores principales:	Anderson, Warren, Barahmand-pour-Whitman, Fariba, Linsley, Peter S, Cerosaletti, Karen, Buckner, Jane H, Rawlings, David J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065793/ https://www.ncbi.nlm.nih.gov/pubmed/36961507 http://dx.doi.org/10.7554/eLife.81577

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