TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks

53BP1 promotes nonhomologous end joining (NHEJ) over homologous recombination (HR) repair by mediating inactivation of DNA end resection. Ubiquitination plays an important role in regulating dissociation of 53BP1 from DNA double-strand breaks (DSBs). However, how this process is regulated remains po...

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Detalles Bibliográficos
Autores principales: Ma, Jian, Zhou, Yingke, Pan, Penglin, Yu, Haixin, Wang, Zixi, Li, Lei Lily, Wang, Bing, Yan, Yuqian, Pan, Yunqian, Ye, Qi, Liu, Tianjie, Feng, Xiaoyu, Xu, Shan, Wang, Ke, Wang, Xinyang, Jian, Yanlin, Ma, Bohan, Fan, Yizeng, Gao, Yang, Huang, Haojie, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066190/
https://www.ncbi.nlm.nih.gov/pubmed/37002234
http://dx.doi.org/10.1038/s41467-023-37499-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066190/
https://www.ncbi.nlm.nih.gov/pubmed/37002234
http://dx.doi.org/10.1038/s41467-023-37499-5

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