Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction

To achieve substrate specificity, protein phosphate 1 (PP1) forms holoenzymes with hundreds of regulatory and inhibitory proteins. Inhibitor-3 (I3) is an ancient inhibitor of PP1 with putative roles in PP1 maturation and the regulation of PP1 activity. Here, we show that I3 residues 27–68 are necess...

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Detalles Bibliográficos
Autores principales: Srivastava, Gautam, Choy, Meng S., Bolik-Coulon, Nicolas, Page, Rebecca, Peti, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066265/
https://www.ncbi.nlm.nih.gov/pubmed/37002212
http://dx.doi.org/10.1038/s41467-023-37372-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066265/
https://www.ncbi.nlm.nih.gov/pubmed/37002212
http://dx.doi.org/10.1038/s41467-023-37372-5

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