Cargando…
Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening
Poly(A)-specific ribonuclease (PARN) is a 3′-exoribonuclease that removes poly(A) tails from the 3′ end of RNAs. PARN is known to deadenylate some ncRNAs, including hTR, Y RNAs, and some miRNAs and thereby enhance their stability by limiting the access of 3′ to 5′ exonucleases recruited by oligo(A)...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066322/ https://www.ncbi.nlm.nih.gov/pubmed/37002320 http://dx.doi.org/10.1038/s41598-023-32039-z |