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Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening

Poly(A)-specific ribonuclease (PARN) is a 3′-exoribonuclease that removes poly(A) tails from the 3′ end of RNAs. PARN is known to deadenylate some ncRNAs, including hTR, Y RNAs, and some miRNAs and thereby enhance their stability by limiting the access of 3′ to 5′ exonucleases recruited by oligo(A)...

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Detalles Bibliográficos
Autores principales:	Huynh, Thao Ngoc, Shukla, Siddharth, Reigan, Philip, Parker, Roy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066322/ https://www.ncbi.nlm.nih.gov/pubmed/37002320 http://dx.doi.org/10.1038/s41598-023-32039-z

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