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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop homeostasis, we report a more open screening of factors whose depletion causes...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066596/ https://www.ncbi.nlm.nih.gov/pubmed/36827184 http://dx.doi.org/10.1016/j.celrep.2023.112148 |