Cargando…

Protocol for a feasibility randomized controlled trial to evaluate the efficacy, safety and tolerability of N-acetylcysteine in reducing adverse drug reactions among adults treated for multidrug-resistant tuberculosis in Tanzania

BACKGROUND: Adverse drug reactions (ADRs) frequently occur in patients using second-line anti-tuberculosis medicine for treatment of multidrug resistant tuberculosis (MDR-TB). ADRs contribute to treatment interruptions which can compromise treatment response and risk acquired drug resistance to crit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mpagama, Stellah G., Mvungi, Happiness C., Mbelele, Peter M., Semvua, Hadija H., Liyoyo, Alphonce A., de Guex, Kristen Petros, Sloan, Derek, Kibiki, Gibson S., Boeree, Martin, Phillips, Patrick P. J., Heysell, Scott K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066962/ https://www.ncbi.nlm.nih.gov/pubmed/37005695 http://dx.doi.org/10.1186/s40814-023-01281-7

Ejemplares similares

Gridlock from diagnosis to treatment of multidrug resistant tuberculosis (MDR-TB) in Tanzania: patients’ perspectives from a focus group discussion
por: Mpagama, Stellah G., et al.
Publicado: (2020)

Application of quantitative second-line drug susceptibility testing at a multidrug-resistant tuberculosis hospital in Tanzania
por: Mpagama, Stellah G, et al.
Publicado: (2013)

Gridlock from Diagnosis to Treatment of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania: Illuminating Potential Factors for Possible Intervention
por: Liyoyo, Alphonce A, et al.
Publicado: (2017)

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania
por: Mpagama, Stellah G., et al.
Publicado: (2013)

Gridlock from diagnosis to treatment of multidrug-resistant tuberculosis in Tanzania: low accessibility of molecular diagnostic services and lack of healthcare worker empowerment in 28 districts of 5 high burden TB regions with mixed methods evaluation
por: Mpagama, Stellah G., et al.
Publicado: (2019)

Underestimated pyrazinamide resistance may compromise outcomes of pyrazinamide containing regimens for treatment of drug susceptible and multi-drug-resistant tuberculosis in Tanzania
por: Juma, Saumu Pazia, et al.
Publicado: (2019)

Pharmacodynamic Biomarkers for Quantifying the Mycobacterial Effect of High Doses of Rifampin in Patients with Rifampin-susceptible Pulmonary Tuberculosis
por: Said, Bibie N, et al.
Publicado: (2021)

Levofloxacin pharmacokinetics in saliva as measured by a mobile microvolume UV spectrophotometer among people treated for rifampicin-resistant TB in Tanzania
por: Mohamed, Sagal, et al.
Publicado: (2021)

Diagnostic Opportunities for Optimizing Management of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania
por: Mpagama, Stellah G
Publicado: (2018)

Atripla(R)/anti-TB combination in TB/HIV patients. Drug in focus
por: Semvua, Hadija H, et al.
Publicado: (2011)

Determination of plasma concentrations of levofloxacin by high performance liquid chromatography for use at a multidrug-resistant tuberculosis hospital in Tanzania
por: Ebers, Andrew, et al.
Publicado: (2017)

Multiple Pathogens Contribute to Human Immunodeficiency Virus-Related Sepsis in Addition to Mycobacterium tuberculosis: A Prospective Cohort in Tanzania
por: Tsere, Donatus Bonphace, et al.
Publicado: (2022)

Whole-genome sequencing of SARS-CoV-2 isolates from symptomatic and asymptomatic individuals in Tanzania
por: Mziray, Shabani Ramadhani, et al.
Publicado: (2023)

Mycobactericidal Effects of Different Regimens Measured by Molecular Bacterial Load Assay among People Treated for Multidrug-Resistant Tuberculosis in Tanzania
por: Mbelele, Peter M., et al.
Publicado: (2021)

Comparison of Overnight Pooled and Standard Sputum Collection Method for Patients with Suspected Pulmonary Tuberculosis in Northern Tanzania
por: Mpagama, Stellah G., et al.
Publicado: (2012)

Meta-Narrative Review of Molecular Methods for Diagnosis and Monitoring of Multidrug-Resistant Tuberculosis Treatment in Adults
por: Mbelele, Peter M., et al.
Publicado: (2018)

Improved performance of Xpert MTB/RIF assay on sputum sediment samples obtained from presumptive pulmonary tuberculosis cases at Kibong’oto infectious diseases hospital in Tanzania
por: Mbelele, Peter M., et al.
Publicado: (2017)

TB or not TB? Definitive determination of species within the M ycobacterium tuberculosis complex in unprocessed sputum from adults with presumed multidrug‐resistant tuberculosis
por: Mbelele, Peter M., et al.
Publicado: (2021)

Improvement in Plasma Drug Activity during the Early Treatment Interval among Tanzanian Patients with Multidrug-Resistant Tuberculosis
por: Ndusilo, Norah D., et al.
Publicado: (2015)

Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania
por: Mbelele, Peter M., et al.
Publicado: (2022)

Implementation of the ‘Removed Injectable modified Short-course regimens for EXpert Multidrug Resistant Tuberculosis’ (RISE study) in Tanzania: a protocol for a mixed-methods process evaluation
por: Kalolo, Albino, et al.
Publicado: (2022)

Use of a molecular bacterial load assay to distinguish between active TB and post-TB lung disease
por: Mbelele, P. M., et al.
Publicado: (2022)

Evaluation of the Antibody in Lymphocyte Supernatant Assay to Detect Active Tuberculosis
por: Sariko, Margaretha, et al.
Publicado: (2017)

Clinical-demographic markers for improving diabetes mellitus diagnosis in people with tuberculosis in Tanzania
por: Byashalira, Kenneth Cleophace, et al.
Publicado: (2022)

Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania
por: Katale, Bugwesa Z., et al.
Publicado: (2020)

Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy
por: Ahmed, Mohamed I. M., et al.
Publicado: (2018)

Predictors of non-adherence to antiretroviral therapy among HIV infected patients in northern Tanzania
por: Semvua, Seleman Khamis, et al.
Publicado: (2017)

Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial
por: Said, Bibie, et al.
Publicado: (2022)

Population Pharmacokinetics of Levofloxacin and Moxifloxacin, and the Probability of Target Attainment in Ethiopian Patients with Multidrug-Resistant Tuberculosis
por: Sidamo, Temesgen, et al.
Publicado: (2022)

Incongruity Between Knowledge and Preventive Practices on Hepatitis B Infection Among University Students in Northeastern, Tanzania
por: Erick, Eward, et al.
Publicado: (2023)

Prevalence and factors associated with tuberculosis among the mining communities in Mererani, Tanzania
por: Mbuya, Alexander W., et al.
Publicado: (2023)

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis
por: Operario, Darwin J., et al.
Publicado: (2017)

Correction: Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis
por: Operario, Darwin J., et al.
Publicado: (2017)

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial
por: Boeree, Martin J, et al.
Publicado: (2017)

Protocol for establishing an Adaptive Diseases control Expert Programme in Tanzania (ADEPT) for integrating care of communicable and non-communicable diseases using tuberculosis and diabetes as a case study
por: Mpagama, Stellah G, et al.
Publicado: (2021)

Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania
por: Sonda, Tolbert, et al.
Publicado: (2018)

Effect of diabetes mellitus on TB drug concentrations in Tanzanian patients
por: Mtabho, Charles M, et al.
Publicado: (2019)

Whole genome sequencing reveals high clonal diversity of Escherichia coli isolated from patients in a tertiary care hospital in Moshi, Tanzania
por: Sonda, Tolbert, et al.
Publicado: (2018)

Implementation and effectiveness of evriMED with short messages service (SMS) reminders and tailored feedback compared to standard care on adherence to treatment among tuberculosis patients in Kilimanjaro, Tanzania: proposal for a cluster randomized controlled trial
por: Sumari-de Boer, Marion, et al.
Publicado: (2019)

Using WGS to identify antibiotic resistance genes and predict antimicrobial resistance phenotypes in MDR Acinetobacter baumannii in Tanzania
por: Kumburu, Happiness H, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jr67s81ohfhpbef0gof1tb0kqr