Development of drugs targeting hypoxia‐inducible factor against tumor cells with VHL mutation: Story of 127 years

Intratumoral hypoxia is associated with tumor progression and therapeutic resistance. The VHL tumor suppressor gene was identified in 1993, and later studies revealed that the gene product pVHL interacts with other proteins to form the VBC complex. The VBC complex functions as an E3 ubiquitin ligase...

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Detalles Bibliográficos
Autores principales: Takamori, Hajime, Yamasaki, Toshinari, Kitadai, Rui, Minamishima, Yoji Andrew, Nakamura, Eijiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067407/
https://www.ncbi.nlm.nih.gov/pubmed/36650918
http://dx.doi.org/10.1111/cas.15728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067407/
https://www.ncbi.nlm.nih.gov/pubmed/36650918
http://dx.doi.org/10.1111/cas.15728

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