Cargando…

Development of drugs targeting hypoxia‐inducible factor against tumor cells with VHL mutation: Story of 127 years

Intratumoral hypoxia is associated with tumor progression and therapeutic resistance. The VHL tumor suppressor gene was identified in 1993, and later studies revealed that the gene product pVHL interacts with other proteins to form the VBC complex. The VBC complex functions as an E3 ubiquitin ligase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takamori, Hajime, Yamasaki, Toshinari, Kitadai, Rui, Minamishima, Yoji Andrew, Nakamura, Eijiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067407/ https://www.ncbi.nlm.nih.gov/pubmed/36650918 http://dx.doi.org/10.1111/cas.15728

Ejemplares similares

Playing Tag with HIF: The VHL Story
por: Leung, Sherri K., et al.
Publicado: (2002)

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
por: Wykoff, C C, et al.
Publicado: (2004)

VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018)

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
por: TAYLOR, CLAIRE, et al.
Publicado: (2012)

Identification of 3 novel VHL germ-line mutations in Danish VHL patients
por: Dandanell, Mette, et al.
Publicado: (2012)

VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
por: Artemov, Artem V., et al.
Publicado: (2018)

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
por: Li, Mingqing, et al.
Publicado: (2011)

Detection of von Hippel‐Lindau gene mutation in circulating cell‐free DNA for clear cell renal cell carcinoma
por: Sumiyoshi, Takayuki, et al.
Publicado: (2021)

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification
por: Cai, Qiliang, et al.
Publicado: (2010)

The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation
por: Buart, Stéphanie, et al.
Publicado: (2021)

RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.
por: Frost, Julianty, et al.
Publicado: (2019)

The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
por: Minervini, Giovanni, et al.
Publicado: (2020)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

AB175. The first large-scale study of VHL gene mutation spectrum and genotype-phenotype correlationship of VHL disease in China
por: Peng, Shuanghe, et al.
Publicado: (2015)

TFEB ‐translocated and ‐amplified renal cell carcinoma with VEGFA co‐amplification: A case of long‐term control by multimodal therapy including a vascular endothelial growth factor‐receptor inhibitor
por: Takamori, Hajime, et al.
Publicado: (2023)

Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL
por: Hasanov, E, et al.
Publicado: (2017)

Germline mutations in TMEM127 confer susceptibility to pheochromocytoma
por: Qin, Yuejuan, et al.
Publicado: (2010)

Pheochromocytomatosis associated with a novel TMEM127 mutation
por: Yu, Run, et al.
Publicado: (2017)

Treatment Strategies for Non-Small Cell Lung Cancer Harboring Common and Uncommon EGFR Mutations: Drug Sensitivity Based on Exon Classification, and Structure-Function Analysis
por: Kitadai, Rui, et al.
Publicado: (2022)

New Insights Into Pheochromocytoma Surveillance of Young Patients With VHL Missense Mutations
por: Fagundes, Gustavo F C, et al.
Publicado: (2019)

Potential Role of VHL, PTEN, and BAP1 Mutations in Renal Tumors
por: Szegedi, Krisztián, et al.
Publicado: (2023)

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
por: McRonald, Fiona E, et al.
Publicado: (2009)

Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome
por: Shmueli, Merav D., et al.
Publicado: (2014)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
por: Mathó, Cecilia, et al.
Publicado: (2022)

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
por: van Hagen, Martijn, et al.
Publicado: (2010)

PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells
por: Chien, W, et al.
Publicado: (2013)

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance
por: Razafinjatovo, Caroline, et al.
Publicado: (2016)

VHL Type 2B Mutations Retain VBC Complex Form and Function
por: Hacker, Kathryn E., et al.
Publicado: (2008)

Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma
por: Charbotel, Barbara, et al.
Publicado: (2007)

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice
por: Albers, Joachim, et al.
Publicado: (2013)

Seven Novel Genes Related to Cell Proliferation and Migration of VHL-Mutated Pheochromocytoma
por: Gao, Shuai, et al.
Publicado: (2021)

Delayed Cardiac Metastasis from Renal Cell Carcinoma Caused by VHL Mutation
por: Sudduth, Christopher L., et al.
Publicado: (2023)

Hypercalcemia in Pheochromocytoma: From MEN to VHL
por: Mittal, Madhukar, et al.
Publicado: (2021)

Volume 127 - Contents
Publicado: (2005)

Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein
por: Frost, Julianty, et al.
Publicado: (2021)

Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
por: Gemmill, R M, et al.
Publicado: (2005)

VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo
por: Lee, C M, et al.
Publicado: (2009)

MON-376 A Novel Mutation in VHL Gene as Posible Cause of Metastasic Pheocromocytoma
por: Montes Barrón, Diego, et al.
Publicado: (2019)

VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Comprehensive characterization of Alu‐mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families
por: Vocke, Cathy D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_59ljgbaud5af2e4heercdsejp0