RNAi screening reveals a synthetic chemical–genetic interaction between ATP synthase and PFK1 in cancer cells

To meet cellular bioenergetic and biosynthetic demands, cancer cells remodel their metabolism to increase glycolytic flux, a phenomenon known as the Warburg effect and believed to contribute to cancer malignancy. Among glycolytic enzymes, phosphofructokinase‐1 (PFK1) has been shown to act as a rate‐...

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Detalles Bibliográficos
Autores principales: Kobayashi, Hiroki, Takase, Shohei, Nishimura, Haruna, Matsumoto, Ken, Harada, Hironori, Yoshida, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067418/
https://www.ncbi.nlm.nih.gov/pubmed/36601784
http://dx.doi.org/10.1111/cas.15713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067418/
https://www.ncbi.nlm.nih.gov/pubmed/36601784
http://dx.doi.org/10.1111/cas.15713

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