Cargando…

In vivo quantitative high-throughput screening for drug discovery and comparative toxicology

Quantitative high-throughput screening (qHTS) pharmacologically evaluates chemical libraries for therapeutic uses, toxicological risk and, increasingly, for academic probe discovery. Phenotypic high-throughput screening assays interrogate molecular pathways, often relying on cell culture systems, hi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dranchak, Patricia K., Oliphant, Erin, Queme, Bryan, Lamy, Laurence, Wang, Yuhong, Huang, Ruili, Xia, Menghang, Tao, Dingyin, Inglese, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2023
Materias:	Resource Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067442/ https://www.ncbi.nlm.nih.gov/pubmed/36786055 http://dx.doi.org/10.1242/dmm.049863

Ejemplares similares

qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data
por: Queme, Bryan, et al.
Publicado: (2023)

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors
por: Miller, Thomas W., et al.
Publicado: (2019)

Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens
por: Clausse, Victor, et al.
Publicado: (2019)

Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases
por: Wiedmann, Mareike, et al.
Publicado: (2021)

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission
por: Plouffe, David M., et al.
Publicado: (2016)

Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening
por: Xia, Menghang, et al.
Publicado: (2008)

A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators
por: Ciulla, Daniel A., et al.
Publicado: (2022)

Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests
por: Szymański, Paweł, et al.
Publicado: (2011)

Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1
por: García-Alcover, Irma, et al.
Publicado: (2014)

A Genome-Scale Vector Resource Enables High-Throughput Reverse Genetic Screening in a Malaria Parasite
por: Gomes, Ana Rita, et al.
Publicado: (2015)

High‐throughput identification of RNA nuclear enrichment sequences
por: Shukla, Chinmay J, et al.
Publicado: (2018)

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs
por: Merkert, Sylvia, et al.
Publicado: (2019)

GenomeVIP: a cloud platform for genomic variant discovery and interpretation
por: Mashl, R. Jay, et al.
Publicado: (2017)

Evaluation of e-liquid toxicity using an open-source high-throughput screening assay
por: Sassano, M. Flori, et al.
Publicado: (2018)

Assessment of spatial transcriptomics for oncology discovery
por: Lyubetskaya, Anna, et al.
Publicado: (2022)

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells
por: D'Antonio, Matteo, et al.
Publicado: (2017)

DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
por: Zhou, Wanding, et al.
Publicado: (2022)

Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor
por: Lynch, Caitlin, et al.
Publicado: (2015)

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators
por: Scheibe, Marion, et al.
Publicado: (2013)

Genome-wide discovery of human splicing branchpoints
por: Mercer, Tim R., et al.
Publicado: (2015)

DisCVR: Rapid viral diagnosis from high-throughput sequencing data
por: Maabar, Maha, et al.
Publicado: (2019)

Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells
por: Tristan, Carlos A., et al.
Publicado: (2021)

High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells
por: Schmitt, Danielle L., et al.
Publicado: (2023)

A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics
por: Tüshaus, Johanna, et al.
Publicado: (2023)

Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling
por: Singec, Ilyas, et al.
Publicado: (2016)

Advancing Toxicology Research Using In Vivo High Throughput Toxicology with Small Fish Models
por: Planchart, Antonio, et al.
Publicado: (2016)

A high‐throughput method to identify trans‐activation domains within transcription factor sequences
por: Arnold, Cosmas D, et al.
Publicado: (2018)

sppIDer: A Species Identification Tool to Investigate Hybrid Genomes with High-Throughput Sequencing
por: Langdon, Quinn K, et al.
Publicado: (2018)

STEAK: A specific tool for transposable elements and retrovirus detection in high-throughput sequencing data
por: Santander, Cindy G., et al.
Publicado: (2017)

Hackathons as a means of accelerating scientific discoveries and knowledge transfer
por: Ghouila, Amel, et al.
Publicado: (2018)

Fast Quantitative Real-Time PCR-Based Screening for Common Chromosomal Aneuploidies in Mouse Embryonic Stem Cells
por: D’Hulst, Charlotte, et al.
Publicado: (2013)

A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
por: Guillen, Katrin P., et al.
Publicado: (2022)

Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis
por: Guy, Michael P., et al.
Publicado: (2014)

Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor
por: Hsu, Chia-Wen, et al.
Publicado: (2014)

Discordant calls across genotype discovery approaches elucidate variants with systematic errors
por: Atkinson, Elizabeth G., et al.
Publicado: (2023)

A quantitative atlas of polyadenylation in five mammals
por: Derti, Adnan, et al.
Publicado: (2012)

Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform
por: Freitas, Jaime, et al.
Publicado: (2014)

Quantitative Map of Proteome Dynamics during Neuronal Differentiation
por: Frese, Christian K., et al.
Publicado: (2017)

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
por: Kiskinis, Evangelos, et al.
Publicado: (2018)

High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition
por: Krishna, Shagun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uugvva4fd8a8q2hff5e6mm8hi6