Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis

BACKGROUND: Inflammatory cytokine interleukin‐6 (IL‐6) plays a pivotal role in skeletal muscle degradation after intra‐abdominal sepsis (IAS), with mechanism remained to be elucidated. Indoleamine 2,3‐dioxygenase 1 (IDO‐1), a key enzyme in converting tryptophan into kynurenine, could be activated by...

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Detalles Bibliográficos
Autores principales: Xie, Tingbin, Lv, Tengfei, Zhang, Tenghui, Feng, Dengyu, Zhu, Feng, Xu, Yi, Zhang, Liang, Gu, Lili, Guo, Zhen, Ding, Chao, Gong, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067504/
https://www.ncbi.nlm.nih.gov/pubmed/36880228
http://dx.doi.org/10.1002/jcsm.13193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067504/
https://www.ncbi.nlm.nih.gov/pubmed/36880228
http://dx.doi.org/10.1002/jcsm.13193

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