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Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis
BACKGROUND: Inflammatory cytokine interleukin‐6 (IL‐6) plays a pivotal role in skeletal muscle degradation after intra‐abdominal sepsis (IAS), with mechanism remained to be elucidated. Indoleamine 2,3‐dioxygenase 1 (IDO‐1), a key enzyme in converting tryptophan into kynurenine, could be activated by...
Autores principales: | Xie, Tingbin, Lv, Tengfei, Zhang, Tenghui, Feng, Dengyu, Zhu, Feng, Xu, Yi, Zhang, Liang, Gu, Lili, Guo, Zhen, Ding, Chao, Gong, Jianfeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067504/ https://www.ncbi.nlm.nih.gov/pubmed/36880228 http://dx.doi.org/10.1002/jcsm.13193 |
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