N-terminal acetylation can stabilize proteins independent of their ubiquitination

The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation. Contrasting these findings, proteome-wide stability measurem...

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Detalles Bibliográficos
Autores principales: van de Kooij, Bert, de Vries, Evert, Rooswinkel, Rogier W., Janssen, George M. C., Kok, Frédérique K., van Veelen, Peter A., Borst, Jannie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067848/
https://www.ncbi.nlm.nih.gov/pubmed/37005459
http://dx.doi.org/10.1038/s41598-023-32380-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067848/
https://www.ncbi.nlm.nih.gov/pubmed/37005459
http://dx.doi.org/10.1038/s41598-023-32380-3

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