Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment

Reduction of the rapid delayed rectifier potassium current (I (Kr)) via drug binding to the human Ether-à-go-go-Related Gene (hERG) channel is a well recognised mechanism that can contribute to an increased risk of Torsades de Pointes. Mathematical models have been created to replicate the effects o...

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Detalles Bibliográficos
Autores principales: Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David J., Lei, Chon Lok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067903/
https://www.ncbi.nlm.nih.gov/pubmed/37021055
http://dx.doi.org/10.3389/fphar.2023.1110555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067903/
https://www.ncbi.nlm.nih.gov/pubmed/37021055
http://dx.doi.org/10.3389/fphar.2023.1110555

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