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Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment
Reduction of the rapid delayed rectifier potassium current (I (Kr)) via drug binding to the human Ether-à-go-go-Related Gene (hERG) channel is a well recognised mechanism that can contribute to an increased risk of Torsades de Pointes. Mathematical models have been created to replicate the effects o...
Autores principales: | Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David J., Lei, Chon Lok |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067903/ https://www.ncbi.nlm.nih.gov/pubmed/37021055 http://dx.doi.org/10.3389/fphar.2023.1110555 |
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