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(667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation

PURPOSE: Serological responses to Covid-19 vaccines in adults post solid organ transplant are impaired [1]. We sought to measure antibodies to SARS-CoV-2 in adolescents post lung, heart, kidney-liver and kidney transplant following the vaccine rollout to 12-17 year-olds in the UK. METHODS: We measur...

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Autores principales: Brugha, R., Davis, E., Low, N., O'Connor, E., Marks, S., Mai, A., Johnson, M., Gilmour, K., Simmonds, J., Grandjean, L., Spencer, H., Goldblatt, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068085/
http://dx.doi.org/10.1016/j.healun.2023.02.681
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author Brugha, R.
Davis, E.
Low, N.
O'Connor, E.
Marks, S.
Mai, A.
Johnson, M.
Gilmour, K.
Simmonds, J.
Grandjean, L.
Spencer, H.
Goldblatt, D.
author_facet Brugha, R.
Davis, E.
Low, N.
O'Connor, E.
Marks, S.
Mai, A.
Johnson, M.
Gilmour, K.
Simmonds, J.
Grandjean, L.
Spencer, H.
Goldblatt, D.
author_sort Brugha, R.
collection PubMed
description PURPOSE: Serological responses to Covid-19 vaccines in adults post solid organ transplant are impaired [1]. We sought to measure antibodies to SARS-CoV-2 in adolescents post lung, heart, kidney-liver and kidney transplant following the vaccine rollout to 12-17 year-olds in the UK. METHODS: We measured anti-spike, receptor binding domain and nucleocapsid IgG in adolescents attending our centre for routine drug monitoring after Pfizer/BioNTech BNT 162b2 was made available in autumn 2021, and collected information on prior infection from electronic records and via patient/parent recall. RESULTS: Samples were obtained from 42 participants, with paired samples pre and post vaccine in 14 patients. 52% had serological evidence of past exposure at baseline (fig 1). Receptor binding domain IgG was positive in all subjects at follow up, with spike IgG positive in 13/14 (p<0.001, fig 2). Individuals who had received vaccine and been infected had higher levels of spike IgG than those who had been infected and unvaccinated (p<0.05). CONCLUSION: All subjects demonstrated antibody responses to vaccine, and vaccine increases antibody levels in adolescents who have also had a SARS-CoV-2 infection in comparison to the unvaccinated. These data support an age-related relationship to antibody responses in post solid organ transplant recipients and support efforts to increase vaccine uptake in this at-risk group.
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spelling pubmed-100680852023-04-03 (667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation Brugha, R. Davis, E. Low, N. O'Connor, E. Marks, S. Mai, A. Johnson, M. Gilmour, K. Simmonds, J. Grandjean, L. Spencer, H. Goldblatt, D. J Heart Lung Transplant Article PURPOSE: Serological responses to Covid-19 vaccines in adults post solid organ transplant are impaired [1]. We sought to measure antibodies to SARS-CoV-2 in adolescents post lung, heart, kidney-liver and kidney transplant following the vaccine rollout to 12-17 year-olds in the UK. METHODS: We measured anti-spike, receptor binding domain and nucleocapsid IgG in adolescents attending our centre for routine drug monitoring after Pfizer/BioNTech BNT 162b2 was made available in autumn 2021, and collected information on prior infection from electronic records and via patient/parent recall. RESULTS: Samples were obtained from 42 participants, with paired samples pre and post vaccine in 14 patients. 52% had serological evidence of past exposure at baseline (fig 1). Receptor binding domain IgG was positive in all subjects at follow up, with spike IgG positive in 13/14 (p<0.001, fig 2). Individuals who had received vaccine and been infected had higher levels of spike IgG than those who had been infected and unvaccinated (p<0.05). CONCLUSION: All subjects demonstrated antibody responses to vaccine, and vaccine increases antibody levels in adolescents who have also had a SARS-CoV-2 infection in comparison to the unvaccinated. These data support an age-related relationship to antibody responses in post solid organ transplant recipients and support efforts to increase vaccine uptake in this at-risk group. Published by Elsevier Inc. 2023-04 2023-04-03 /pmc/articles/PMC10068085/ http://dx.doi.org/10.1016/j.healun.2023.02.681 Text en Copyright © 2023 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Brugha, R.
Davis, E.
Low, N.
O'Connor, E.
Marks, S.
Mai, A.
Johnson, M.
Gilmour, K.
Simmonds, J.
Grandjean, L.
Spencer, H.
Goldblatt, D.
(667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation
title (667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation
title_full (667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation
title_fullStr (667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation
title_full_unstemmed (667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation
title_short (667) Antibody Response to Sars-Cov-2 Vaccination in Adolescents Following Solid Organ Transplantation
title_sort (667) antibody response to sars-cov-2 vaccination in adolescents following solid organ transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068085/
http://dx.doi.org/10.1016/j.healun.2023.02.681
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