Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates

T cells use their T‐cell receptors (TCRs) to discriminate between lower‐affinity self and higher‐affinity foreign peptide major‐histocompatibility‐complexes (pMHCs) based on the TCR/pMHC off‐rate. It is now appreciated that T cells generate mechanical forces during this process but how force impacts...

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Detalles Bibliográficos
Autores principales: Pettmann, Johannes, Awada, Lama, Różycki, Bartosz, Huhn, Anna, Faour, Sara, Kutuzov, Mikhail, Limozin, Laurent, Weikl, Thomas R, van der Merwe, P Anton, Robert, Philippe, Dushek, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068313/
https://www.ncbi.nlm.nih.gov/pubmed/36484367
http://dx.doi.org/10.15252/embj.2022111841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068313/
https://www.ncbi.nlm.nih.gov/pubmed/36484367
http://dx.doi.org/10.15252/embj.2022111841

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