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Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates
T cells use their T‐cell receptors (TCRs) to discriminate between lower‐affinity self and higher‐affinity foreign peptide major‐histocompatibility‐complexes (pMHCs) based on the TCR/pMHC off‐rate. It is now appreciated that T cells generate mechanical forces during this process but how force impacts...
Autores principales: | Pettmann, Johannes, Awada, Lama, Różycki, Bartosz, Huhn, Anna, Faour, Sara, Kutuzov, Mikhail, Limozin, Laurent, Weikl, Thomas R, van der Merwe, P Anton, Robert, Philippe, Dushek, Omer |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068313/ https://www.ncbi.nlm.nih.gov/pubmed/36484367 http://dx.doi.org/10.15252/embj.2022111841 |
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