DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP (cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used glioblastoma cells that show undetectable cGAS levels to address if alternat...

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Detalles Bibliográficos
Autores principales: Taffoni, Clara, Marines, Johanna, Chamma, Hanane, Guha, Soumyabrata, Saccas, Mathilde, Bouzid, Amel, Valadao, Ana‐Luiza Chaves, Maghe, Clément, Jardine, Jane, Park, Mi Kyung, Polak, Katarzyna, De Martino, Mara, Vanpouille‐Box, Claire, Del Rio, Maguy, Gongora, Celine, Gavard, Julie, Bidère, Nicolas, Song, Min Sup, Pineau, Donovan, Hugnot, Jean‐Philippe, Kissa, Karima, Fontenille, Laura, Blanchet, Fabien P, Vila, Isabelle K, Laguette, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068334/
https://www.ncbi.nlm.nih.gov/pubmed/36574362
http://dx.doi.org/10.15252/embj.2022111961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068334/
https://www.ncbi.nlm.nih.gov/pubmed/36574362
http://dx.doi.org/10.15252/embj.2022111961

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