Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma

Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastatic cutaneous melanoma specifically amplify resistan...

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Detalles Bibliográficos
Autores principales: Dharanipragada, Prashanthi, Zhang, Xiao, Liu, Sixue, Lomeli, Shirley H., Hong, Aayoung, Wang, Yan, Yang, Zhentao, Lo, Kara Z., Vega-Crespo, Agustin, Ribas, Antoni, Moschos, Stergios J., Moriceau, Gatien, Lo, Roger S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068459/
https://www.ncbi.nlm.nih.gov/pubmed/36700848
http://dx.doi.org/10.1158/2159-8290.CD-22-0787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068459/
https://www.ncbi.nlm.nih.gov/pubmed/36700848
http://dx.doi.org/10.1158/2159-8290.CD-22-0787

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