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Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice

AIMS: Amyloid beta (Aβ) is an important pathological feature of Alzheimer's disease (AD). A disintegrin and metalloproteinase 10 (ADAM10) can reduce the production of toxic Aβ by activating the nonamyloidogenic pathway of amyloid precursor protein (APP). We previously found that apicidin, which...

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Detalles Bibliográficos
Autores principales: Luo, Biao, Chen, Jian, Zhou, Gui‐Feng, Xie, Xiao‐Yong, Tang, Jing, Wen, Qi‐Xin, Song, Li, Xie, Shi‐Qi, Long, Yan, Chen, Guo‐Jun, Hu, Xiao‐Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068467/
https://www.ncbi.nlm.nih.gov/pubmed/36708130
http://dx.doi.org/10.1111/cns.14102