Dl‐3‐n‐butylphthalide promotes synaptic plasticity by activating the Akt/ERK signaling pathway and reduces the blood–brain barrier leakage by inhibiting the HIF‐1α/MMP signaling pathway in vascular dementia model mice

AIMS: DL‐3‐n‐butylphthalide (NBP) exerts beneficial effects on global cognitive functions, but the underlying molecular mechanisms are still poorly understood. The present study aimed to investigate whether NBP mediates synaptic plasticity and blood–brain barrier (BBB) function, which play a pivotal...

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Detalles Bibliográficos
Autores principales: Che, Ping, Zhang, Juan, Yu, Mingqian, Tang, Ping, Wang, Yanhui, Lin, Aolei, Xu, Jing, Zhang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068471/
https://www.ncbi.nlm.nih.gov/pubmed/36756709
http://dx.doi.org/10.1111/cns.14112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068471/
https://www.ncbi.nlm.nih.gov/pubmed/36756709
http://dx.doi.org/10.1111/cns.14112

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