Cargando…

Dl‐3‐n‐butylphthalide promotes synaptic plasticity by activating the Akt/ERK signaling pathway and reduces the blood–brain barrier leakage by inhibiting the HIF‐1α/MMP signaling pathway in vascular dementia model mice

AIMS: DL‐3‐n‐butylphthalide (NBP) exerts beneficial effects on global cognitive functions, but the underlying molecular mechanisms are still poorly understood. The present study aimed to investigate whether NBP mediates synaptic plasticity and blood–brain barrier (BBB) function, which play a pivotal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Che, Ping, Zhang, Juan, Yu, Mingqian, Tang, Ping, Wang, Yanhui, Lin, Aolei, Xu, Jing, Zhang, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068471/ https://www.ncbi.nlm.nih.gov/pubmed/36756709 http://dx.doi.org/10.1111/cns.14112

Ejemplares similares

Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling
por: Zhu, Bei-lei, et al.
Publicado: (2018)

Dl-butylphthalide inhibits rotenone-induced oxidative stress in microglia via regulation of the Keap1/Nrf2/HO-1 signaling pathway
por: Luo, Rixin, et al.
Publicado: (2021)

Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway
por: Wang, Wei, et al.
Publicado: (2020)

Protective effects of dl-3n-butylphthalide against diffuse brain injury
por: Zhao, Yaning, et al.
Publicado: (2013)

Dl-3-n-Butylphthalide Alleviates Hippocampal Neuron Damage in Chronic Cerebral Hypoperfusion via Regulation of the CNTF/CNTFRα/JAK2/STAT3 Signaling Pathways
por: Li, Wenxian, et al.
Publicado: (2021)

DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
por: Zhang, Hui, et al.
Publicado: (2023)

Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice
por: Lv, Chaonan, et al.
Publicado: (2018)

Dl-NBP (Dl-3-N-Butylphthalide) Treatment Promotes Neurological Functional Recovery Accompanied by the Upregulation of White Matter Integrity and HIF-1α/VEGF/Notch/Dll4 Expression
por: Wang, Yanping, et al.
Publicado: (2020)

Dl-3-n-butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal-enriched protein tyrosine phosphatase/ERK/cAMP-response element-binding protein signaling pathway
por: Zhao, Yan, et al.
Publicado: (2022)

Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging
por: Liu, Run-Zhe, et al.
Publicado: (2017)

Dl-3-N-Butylphthalide Presents Anti-Cancer Activity in Lung Cancer by Targeting PD-1/PD-L1 Signaling
por: Jiang, Qian, et al.
Publicado: (2021)

Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
por: Chen, Yajing, et al.
Publicado: (2019)

DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice
por: Wei, Zheng Zachory, et al.
Publicado: (2021)

Effects of Dl-3-n-butylphthalide on cognitive functions and blood–brain barrier in chronic cerebral hypoperfusion rats
por: Ma, Yang, et al.
Publicado: (2023)

Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways
por: Wan, Jun, et al.
Publicado: (2016)

[Corrigendum] Dl‑3‑n‑butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal‑enriched protein tyrosine phosphatase/ERK/cAMP‑response element‑binding pro‑tein signaling pathway
por: Zhao, Yan, et al.
Publicado: (2022)

Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis
por: Xu, Jingyu, et al.
Publicado: (2021)

Correction to: Effects of Dl-3‑n‑butylphthalide on cognitive functions and blood–brain barrier in chronic cerebral hypoperfusion rats
por: Ma, Yang, et al.
Publicado: (2023)

Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats
por: Sun, Yanan, et al.
Publicado: (2020)

Dl-3-n-butylphthalide Reduces Neurovascular Inflammation and Ischemic Brain Injury in Mice
por: Yang, Chun-Sheng, et al.
Publicado: (2019)

Corrigendum: Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
por: Chen, Yajing, et al.
Publicado: (2021)

Dl‐3‐N‐butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats
por: Zhou, Pan‐Ting, et al.
Publicado: (2019)

Dl-3-N-Butylphthalide Promotes Angiogenesis in an Optimized Model of Transient Ischemic Attack in C57BL/6 Mice
por: Wang, Jiahui, et al.
Publicado: (2021)

Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway
por: Zhang, Qin, et al.
Publicado: (2021)

Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway
por: Li, Zi-Qi, et al.
Publicado: (2023)

The efficacy and safety of Dl-3n-butylphthalide on progressive cerebral infarction: A randomized controlled STROBE study
por: Zhang, Chenhao, et al.
Publicado: (2017)

Dl‐3‐n‐butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF‐κB signalling
por: He, Zili, et al.
Publicado: (2017)

Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats
por: Zhang, Dongqin, et al.
Publicado: (2022)

Proteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp + -Induced Toxicity via downregulating P53 pathway in N2A Cells
por: Zhao, Yuan, et al.
Publicado: (2023)

Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice
por: Qu, Mengyao, et al.
Publicado: (2020)

Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage
por: Tu, Ewen, et al.
Publicado: (2020)

Dl-3-n-Butylphthalide (NBP) Mitigates Muscular Injury Induced by Limb Ischemia/Reperfusion in Mice through the HMGB1/TLR4/NF-κB Pathway
por: Sun, Huanhuan, et al.
Publicado: (2022)

PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia
por: Zhang, Zhen, et al.
Publicado: (2018)

Fucoidan Stimulates Monocyte Migration via ERK/p38 Signaling Pathways and MMP9 Secretion
por: Sapharikas, Elene, et al.
Publicado: (2015)

LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice
por: Chen, Shenglin, et al.
Publicado: (2020)

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways
por: Willcockson, Helen, et al.
Publicado: (2021)

Efficacy and Safety of DL-3-n-Butylphthalide in the Treatment of Poststroke Cognitive Impairment: A Systematic Review and Meta-Analysis
por: Fan, Xueming, et al.
Publicado: (2022)

dl‐3‐n‐butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion
por: Han, Qin‐Yu, et al.
Publicado: (2019)

Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway
por: Gao, Yaran, et al.
Publicado: (2022)

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia
por: Xu, Gang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g14cclrvtht9qj6qq7mnteko5h