A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice

AIMS: This study was designed to investigate the role of NR2B and the contribution of DNA methylation to NR2B expression in the pathogenesis of PND. METHODS: Eighteen‐month‐old C57BL/6J mice were subjected to experimental laparotomy under 1.4% isoflurane anesthesia. Hippocampus‐dependent learning an...

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Detalles Bibliográficos
Autores principales: Xu, Feifei, Cong, Peilin, Zhang, Bingqian, Dong, Hailong, Zuo, Wenqiang, Wu, Tingmei, Tian, Li, Xiong, Lize
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068472/
https://www.ncbi.nlm.nih.gov/pubmed/36694341
http://dx.doi.org/10.1111/cns.14097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068472/
https://www.ncbi.nlm.nih.gov/pubmed/36694341
http://dx.doi.org/10.1111/cns.14097

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