Proteasome inhibitor bortezomib stabilizes and activates p53 in hematopoietic stem/progenitors and double-negative T cells in vivo

We have previously shown that proteasome inhibitor bortezomib stabilizes p53 in stem and progenitor cells within gastrointestinal tissues. Here, we characterize the effect of bortezomib treatment on primary and secondary lymphoid tissues in mice. We find that bortezomib stabilizes p53 in significant...

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Detalles Bibliográficos
Autores principales: Xue, Yuezhen, San Luis, Boris, Dress, Regine J., Murad, Katzrin Binte Ahmad, Ginhoux, Florent, Barker, Nick, Lane, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068759/
https://www.ncbi.nlm.nih.gov/pubmed/36940336
http://dx.doi.org/10.1073/pnas.2219978120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068759/
https://www.ncbi.nlm.nih.gov/pubmed/36940336
http://dx.doi.org/10.1073/pnas.2219978120

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