The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology

There is significant disease heterogeneity among mouse strains infected with the helminth Schistosoma mansoni. Here, we uncover a unique balance in two critical innate pathways governing the severity of disease. In the low-pathology setting, parasite egg-stimulated dendritic cells (DCs) induce robus...

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Detalles Bibliográficos
Autores principales: Kalantari, Parisa, Shecter, Ilana, Hopkins, Jacob, Pilotta Gois, Andrea, Morales, Yoelkys, Harandi, Bijan F., Sharma, Shruti, Stadecker, Miguel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068786/
https://www.ncbi.nlm.nih.gov/pubmed/36943884
http://dx.doi.org/10.1073/pnas.2211047120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068786/
https://www.ncbi.nlm.nih.gov/pubmed/36943884
http://dx.doi.org/10.1073/pnas.2211047120

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