Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions

The amyotrophic lateral sclerosis–parkinsonism dementia complex (ALS-PDC) of Guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein Lewy bodies, and sparse β-amyloid (Aβ) plaques distributed in the central nervous system. Extensive studies of geneti...

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Detalles Bibliográficos
Autores principales: Condello, Carlo, Ayers, Jacob I., Dalgard, Clifton L., Garcia Garcia, M. Madhy, Rivera, Brianna M., Seeley, William W., Perl, Daniel P., Prusiner, Stanley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068802/
https://www.ncbi.nlm.nih.gov/pubmed/36952379
http://dx.doi.org/10.1073/pnas.2220984120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068802/
https://www.ncbi.nlm.nih.gov/pubmed/36952379
http://dx.doi.org/10.1073/pnas.2220984120

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