Carbon source availability drives nutrient utilization in CD8(+) T cells

How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts glucose utilization by CD8(+) T cells, independent of transcriptional changes in met...

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Detalles Bibliográficos
Autores principales: Kaymak, Irem, Luda, Katarzyna M., Duimstra, Lauren R., Ma, Eric H., Longo, Joseph, Dahabieh, Michael S., Faubert, Brandon, Oswald, Brandon M., Watson, McLane J., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Compton, Shelby E., Fu, Zhen, DeBerardinis, Ralph J., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068808/
https://www.ncbi.nlm.nih.gov/pubmed/35981545
http://dx.doi.org/10.1016/j.cmet.2022.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068808/
https://www.ncbi.nlm.nih.gov/pubmed/35981545
http://dx.doi.org/10.1016/j.cmet.2022.07.012

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