Cargando…

Carbon source availability drives nutrient utilization in CD8(+) T cells

How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts glucose utilization by CD8(+) T cells, independent of transcriptional changes in met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaymak, Irem, Luda, Katarzyna M., Duimstra, Lauren R., Ma, Eric H., Longo, Joseph, Dahabieh, Michael S., Faubert, Brandon, Oswald, Brandon M., Watson, McLane J., Kitchen-Goosen, Susan M., DeCamp, Lisa M., Compton, Shelby E., Fu, Zhen, DeBerardinis, Ralph J., Williams, Kelsey S., Sheldon, Ryan D., Jones, Russell G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068808/ https://www.ncbi.nlm.nih.gov/pubmed/35981545 http://dx.doi.org/10.1016/j.cmet.2022.07.012

Ejemplares similares

(13)C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8(+) T cells
por: Ma, Eric H., et al.
Publicado: (2023)

Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent
por: Suh, Eul Hyun, et al.
Publicado: (2021)

Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
por: Izreig, Said, et al.
Publicado: (2020)

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
por: Griss, Takla, et al.
Publicado: (2015)

Metabolic heterogeneity in cancer
por: DeBerardinis, Ralph J
Publicado: (2014)

Q&A: Targeting metabolism to diagnose and treat cancer
por: DeBerardinis, Ralph J
Publicado: (2014)

Pyruvate dehydrogenase activity is required for optimal growth under lipid deficient conditions
por: Rajagopalan, Kartik, et al.
Publicado: (2014)

Fundamentals of cancer metabolism
por: DeBerardinis, Ralph J., et al.
Publicado: (2016)

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
por: Luengo, Alba, et al.
Publicado: (2019)

From “N of 1” to N of more
por: DeBerardinis, Ralph J., et al.
Publicado: (2015)

Metabolic heterogeneity confers differences in melanoma metastatic potential
por: Tasdogan, Alpaslan, et al.
Publicado: (2019)

Vitamin B6-dependent epilepsy due to pyridoxal phosphate-binding protein (PLPBP) defect – First case report from Pakistan and review of literature
por: Ahmed, Sibtain, et al.
Publicado: (2020)

Assessing the validity of pressure-measuring insoles in quantifying gait variables
por: DeBerardinis, Jessica, et al.
Publicado: (2018)

An ethics curriculum for short-term global health trainees
por: DeCamp, Matthew, et al.
Publicado: (2013)

Use of Pressure-Measuring Insoles to Characterize Gait Parameters in Simulated Reduced-Gravity Conditions
por: Ison, Christian, et al.
Publicado: (2021)

Identifying metabolomic features that predict metastasis of melanoma from a primary site
por: Shi, Xiaolei, et al.
Publicado: (2014)

A comparison of two techniques for center of pressure measurements
por: DeBerardinis, Jessica, et al.
Publicado: (2020)

α-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells
por: Lesner, Nicholas P., et al.
Publicado: (2020)

A Pan-Cancer Assessment of RB1/TP53 Co-Mutations
por: Cai, Ling, et al.
Publicado: (2022)

Dissecting molecular, pathological, and clinical features associated with tumor neural/neuroendocrine heterogeneity
por: Cai, Ling, et al.
Publicado: (2023)

A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
por: Cai, Ling, et al.
Publicado: (2023)

Regulation of Metabolic Activity by p53
por: Flöter, Jessica, et al.
Publicado: (2017)

Prior metabolite extraction fully preserves RNAseq quality and enables integrative multi-‘omics analysis of the liver metabolic response to viral infection
por: Madaj, Zachary B, et al.
Publicado: (2023)

Metabolic changes in cancer cells upon suppression of MYC
por: Anso, Elena, et al.
Publicado: (2013)

A Call to Organize a Society
por: DeCamp, M., et al.
Publicado: (1865)

FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
por: Dai, Wenting, et al.
Publicado: (2023)

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
por: Flowers, Ebony M., et al.
Publicado: (2018)

The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts
por: Shi, Xiaolei, et al.
Publicado: (2017)

Assessing consistency across functional screening datasets in cancer cells
por: Cai, Ling, et al.
Publicado: (2021)

Fighting in a wasteland: deleterious metabolites and antitumor immunity
por: Watson, McLane J., et al.
Publicado: (2022)

Genomic regression analysis of coordinated expression
por: Cai, Ling, et al.
Publicado: (2017)

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
por: Ni, Min, et al.
Publicado: (2019)

Alfabetización temprana /
por: McLane, Joan Brooks
Publicado: (1999)

Membrane Receptors and Cellular Regulation
por: McLane, John A.
Publicado: (1986)

Receptor Biochemistry and Methodology. Volume 4. Monoclonal and Idiotypic Antibody Probes for Receptor Structure and Function
por: McLane, John A.
Publicado: (1985)

The Prone Position during Operations upon the Jaws
por: Tiffany, L. McLane
Publicado: (1883)

Diagnosis of Malignant Tumors of the Upper Jaw in Youth
por: Tiffany, L. McLane
Publicado: (1880)

Plastic Surgery of the Face
por: Tiffany, L. McLane
Publicado: (1884)

Obstinate Epilepsy, Treatment
por: Hamilton, Allan McLane
Publicado: (1874)

The Use of Revulsives in Diseases of the Nervous System
por: Hamilton, Allan McLane
Publicado: (1875)

Cannot write session to /tmp/vufind_sessions/sess_enhtnjemp5iuagoou1qbn0cesq