Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

Poly(ADP-ribose) polymerase-1 (PARP1) has been reported to play an important role in longevity. Here, we showed that the knockdown of the PARP1 extended the lifespan of Drosophila, with particular emphasis on the skeletal muscle. The muscle-specific mutant Drosophila exhibited resistance to starvati...

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Detalles Bibliográficos
Autores principales: Guo, Shanshan, Zhang, Shuang, Zhuang, Yixiao, Xie, Famin, Wang, Ruwen, Kong, Xingyu, Zhang, Qiongyue, Feng, Yonghao, Gao, Huanqing, Kong, Xingxing, Liu, Tiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068811/
https://www.ncbi.nlm.nih.gov/pubmed/36947517
http://dx.doi.org/10.1073/pnas.2213857120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068811/
https://www.ncbi.nlm.nih.gov/pubmed/36947517
http://dx.doi.org/10.1073/pnas.2213857120

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