Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the development of hematopoietic stem cells, germ cells, and other cells. A variety of human cancers, such as acute myeloid leukemia, gastrointestinal stromal tumor, and mast cell leukemia, are driven by somatic...

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Detalles Bibliográficos
Autores principales: Krimmer, Stefan G., Bertoletti, Nicole, Suzuki, Yoshihisa, Katic, Luka, Mohanty, Jyotidarsini, Shu, Sheng, Lee, Sangwon, Lax, Irit, Mi, Wei, Schlessinger, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068818/
https://www.ncbi.nlm.nih.gov/pubmed/36943885
http://dx.doi.org/10.1073/pnas.2300054120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068818/
https://www.ncbi.nlm.nih.gov/pubmed/36943885
http://dx.doi.org/10.1073/pnas.2300054120

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