Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity

Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale conformational changes in the HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] that promote virus entry into the cell. CD4-mimetic compounds (CD4mcs) comprise small organic molecules that bind in the highly conser...

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Detalles Bibliográficos
Autores principales: Fritschi, Christopher J., Anang, Saumya, Gong, Zhen, Mohammadi, Mohammadjavad, Richard, Jonathan, Bourassa, Catherine, Severino, Kenny T., Richter, Hannah, Yang, Derek, Chen, Hung-Ching, Chiu, Ta-Jung, Seaman, Michael S., Madani, Navid, Abrams, Cameron, Finzi, Andrés, Hendrickson, Wayne A., Sodroski, Joseph G., Smith, Amos B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068826/
https://www.ncbi.nlm.nih.gov/pubmed/36961924
http://dx.doi.org/10.1073/pnas.2222073120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068826/
https://www.ncbi.nlm.nih.gov/pubmed/36961924
http://dx.doi.org/10.1073/pnas.2222073120

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