Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduced a relatively large number of mutations, including three mutations in the highly conserved heptad repeat 1 (HR1) region of the spike glycoprotein (S) critical for its membrane fusion activity. We show that...

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Detalles Bibliográficos
Autores principales: Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J. B., White, K. Ian, Pfuetzner, Richard A., Esquivies, Luis, Kirchhausen, Tomas, Brunger, Axel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068829/
https://www.ncbi.nlm.nih.gov/pubmed/36940324
http://dx.doi.org/10.1073/pnas.2300360120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068829/
https://www.ncbi.nlm.nih.gov/pubmed/36940324
http://dx.doi.org/10.1073/pnas.2300360120

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