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Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduced a relatively large number of mutations, including three mutations in the highly conserved heptad repeat 1 (HR1) region of the spike glycoprotein (S) critical for its membrane fusion activity. We show that...

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Detalles Bibliográficos
Autores principales:	Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J. B., White, K. Ian, Pfuetzner, Richard A., Esquivies, Luis, Kirchhausen, Tomas, Brunger, Axel T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068829/ https://www.ncbi.nlm.nih.gov/pubmed/36940324 http://dx.doi.org/10.1073/pnas.2300360120

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