Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies

Selection and development of monoclonal antibody (mAb) therapeutics against pathogenic viruses depends on certain functional characteristics. Neutralization potency, or the half-maximal inhibitory concentration (IC(50)) values, is an important characteristic of candidate therapeutic antibodies. Stru...

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Detalles Bibliográficos
Autores principales: Williamson, Lauren E., Bandyopadhyay, Abhishek, Bailey, Kevin, Sirohi, Devika, Klose, Thomas, Julander, Justin G., Kuhn, Richard J., Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068833/
https://www.ncbi.nlm.nih.gov/pubmed/36961925
http://dx.doi.org/10.1073/pnas.2213690120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068833/
https://www.ncbi.nlm.nih.gov/pubmed/36961925
http://dx.doi.org/10.1073/pnas.2213690120

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