O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation

Programmed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) mediate T cell–dependent immunity against tumors. The abundance of cell surface PD-L1 is a key determinant of the efficacy of immune checkpoint blockade therapy targeting PD-L1. However, the regulation of cell surface...

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Detalles Bibliográficos
Autores principales: Zhu, Qiang, Wang, Hongxing, Chai, Siyuan, Xu, Liang, Lin, Bingyi, Yi, Wen, Wu, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068856/
https://www.ncbi.nlm.nih.gov/pubmed/36943877
http://dx.doi.org/10.1073/pnas.2216796120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068856/
https://www.ncbi.nlm.nih.gov/pubmed/36943877
http://dx.doi.org/10.1073/pnas.2216796120

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