Effects of regorafenib on the mononuclear/phagocyte system and how these contribute to the inhibition of colorectal tumors in mice

BACKGROUND: Regorafenib was previously shown to reduce tumor-associated macrophages and potently inhibit colony-stimulating factor 1 receptor (CSF1R), also known as CD115, in biochemical assays. The CSF1R signaling pathway is essential in the biology of the mononuclear/phagocyte system, which can pr...

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Detalles Bibliográficos
Autores principales: Grünewald, Sylvia, Stecklum, Maria, Rizzo, Manuel, Rathjens, Jonathan, Fiebig, Lukas, Zopf, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069031/
https://www.ncbi.nlm.nih.gov/pubmed/37013652
http://dx.doi.org/10.1186/s40001-023-01099-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069031/
https://www.ncbi.nlm.nih.gov/pubmed/37013652
http://dx.doi.org/10.1186/s40001-023-01099-2

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