Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred prophylactic response to epidemics and pandemics. However, for individuals who have contracted the disease, the rapid design of antibodies tha...

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Detalles Bibliográficos
Autores principales: Hernandez, Nancy E., Jankowski, Wojciech, Frick, Rahel, Kelow, Simon P., Lubin, Joseph H., Simhadri, Vijaya, Adolf-Bryfogle, Jared, Khare, Sagar D., Dunbrack, Roland L., Gray, Jeffrey J., Sauna, Zuben E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069166/
https://www.ncbi.nlm.nih.gov/pubmed/37035348
http://dx.doi.org/10.1016/j.heliyon.2023.e15032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069166/
https://www.ncbi.nlm.nih.gov/pubmed/37035348
http://dx.doi.org/10.1016/j.heliyon.2023.e15032

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