Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring

The mTOR inhibitor sirolimus is prescribed to treat children with varying diseases, ranging from vascular anomalies to sporadic lymphangioleiomyomatosis to transplantation (solid organ or hematopoietic cell). Precision dosing of sirolimus using therapeutic drug monitoring (TDM) of sirolimus concentr...

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Detalles Bibliográficos
Autores principales: Shen, Guofang, Moua, Kao Tang Ying, Perkins, Kathryn, Johnson, Deron, Li, Arthur, Curtin, Peter, Gao, Wei, McCune, Jeannine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069443/
https://www.ncbi.nlm.nih.gov/pubmed/37021042
http://dx.doi.org/10.3389/fphar.2023.1126981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069443/
https://www.ncbi.nlm.nih.gov/pubmed/37021042
http://dx.doi.org/10.3389/fphar.2023.1126981

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