Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry

Pol2 is the leading-strand DNA polymerase in budding yeast. Here we describe an antagonism between its conserved POPS (Pol2 family-specific catalytic core peripheral subdomain) and exonuclease domain and the importance of this antagonism in genome replication. We show that multiple defects caused by...

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Detalles Bibliográficos
Autores principales: Meng, Xiangzhou, Claussin, Clémence, Regan-Mochrie, Gemma, Whitehouse, Iestyn, Zhao, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069448/
https://www.ncbi.nlm.nih.gov/pubmed/36702483
http://dx.doi.org/10.1101/gad.350054.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069448/
https://www.ncbi.nlm.nih.gov/pubmed/36702483
http://dx.doi.org/10.1101/gad.350054.122

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