WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We developed a spatially resolved loss-of-function screen i...

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Detalles Bibliográficos
Autores principales: Mitchell, Kelly, Sprowls, Samuel A., Arora, Sonali, Shakya, Sajina, Silver, Daniel J., Goins, Christopher M., Wallace, Lisa, Roversi, Gustavo, Schafer, Rachel E., Kay, Kristen, Miller, Tyler E., Lauko, Adam, Bassett, John, Kashyap, Anjali, D'Amato Kass, Jonathan, Mulkearns-Hubert, Erin E., Johnson, Sadie, Alvarado, Joseph, Rich, Jeremy N., Holland, Eric C., Paddison, Patrick J., Patel, Anoop P., Stauffer, Shaun R., Hubert, Christopher G., Lathia, Justin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069451/
https://www.ncbi.nlm.nih.gov/pubmed/36732025
http://dx.doi.org/10.1101/gad.349803.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069451/
https://www.ncbi.nlm.nih.gov/pubmed/36732025
http://dx.doi.org/10.1101/gad.349803.122

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